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SHIRE HUMAN GENETIC THERAPIES H-1B Visa Sponsorship & Salary Data

SHIRE HUMAN GENETIC THERAPIES has filed 115 H-1B labor condition applications from FY 2020 to FY 2026, with 110 certified. The median H-1B salary at SHIRE HUMAN GENETIC THERAPIES is $125,000, which is 4% higher than the national H-1B median of $120,000.

110
Certified Filings
FY 2020-2026
$125,000
Median Salary
+4% vs national
0%
Denial Rate
0 denied of 115
7
Years of Data
FY 2020-2026

Salary Analysis

Salary Range

  • 10th percentile: $85,000
  • 25th percentile: $104,000
  • Median: $125,000
  • 75th percentile: $152,193
  • 90th percentile: $180,250

Wage Level Distribution

  • Level I (Entry): 17 (16%)
  • Level II (Qualified): 29 (27%)
  • Level III (Experienced): 17 (16%)
  • Level IV (Expert): 45 (42%)

Trend (2020-2026)

  • Starting median: $116,000
  • Current median: $169,914
  • Growth: +46%

Salary & Hiring Visualizations

Salary Distribution

Distribution of H-1B salaries at SHIRE HUMAN GENETIC THERAPIES

SHIRE HUMAN GENETIC THERAPIES's H-1B salaries range from $85,000 to $180,250 (10th-90th percentile), with a median of $125,000. This is 4% above the national H-1B median.

Wage Level Distribution

DOL wage levels affect H-1B lottery priority

SHIRE HUMAN GENETIC THERAPIES files 84% of H-1B positions at Level II or higher. Higher wage levels receive priority in the H-1B lottery, giving SHIRE HUMAN GENETIC THERAPIES candidates a competitive advantage.

Median Salary Trend

Year-over-year salary changes

SHIRE HUMAN GENETIC THERAPIES's median H-1B salary increased by +46% from FY 2020 ($116,000) to FY 2026 ($169,914). This strong growth reflects competitive compensation adjustments.

H-1B Filings by Year

Annual hiring activity through H-1B program

SHIRE HUMAN GENETIC THERAPIES's H-1B filings changed by -97% from FY 2020 to FY 2026. This may reflect changes in hiring strategy or workforce composition.

Salary by Job Title

Top H-1B job titles at this employer

Senior Validation Engineer
4 filings
$120,000
Research Scientist
3 filings
$117,000
Project Manager
2 filings
$110,000
Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu
2 filings
$192,000
Associate Research Scientist
2 filings
$75,000
Cleaning And Sterilization Validation Senior Engineer
2 filings
$140,000

The highest-volume H-1B role at SHIRE HUMAN GENETIC THERAPIES is Senior Validation Engineer with 4 filings at $120,000 median salary.

Salary by Location

Salary distribution across office locations (sorted by median)

Lexington, MA (80)
$120K
Cambridge, MA (25)
$137K
$50K $125K $200K $300K+

SHIRE HUMAN GENETIC THERAPIES's largest H-1B hub is Lexington, MA with 80 filings. The highest-paying location is Leexington, MA at $176,105 median.

Highest Paying H-1B Roles at SHIRE HUMAN GENETIC THERAPIES

Ranked by median salary — Unlike "Salary by Job Title" above which shows the most common roles by filing volume, this section ranks all H-1B positions by their median compensation to highlight the best-paying opportunities.

These are the top 10 highest-paying H-1B job titles at SHIRE HUMAN GENETIC THERAPIES, ranked by median salary. The highest-paying role is Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu at $192,000 median, which is 54% above the company's overall H-1B median of $125,000.

High-paying H-1B roles typically require advanced technical expertise, specialized domain knowledge, or significant leadership responsibility. Factors influencing top-tier compensation include years of experience, educational credentials (PhD, Master's degrees), rare skill combinations, and market demand for specific technologies. The salary distribution chart below each role shows how compensation varies—wider distributions indicate more salary negotiation flexibility, while narrow peaks suggest standardized pay bands. Senior and principal-level positions consistently command premium salaries due to their strategic impact and scarcity of qualified candidates.

1

Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu

2 H-1B filings at SHIRE HUMAN GENETIC THERAPIES

$192,000
+54% vs company median
2

Cleaning And Sterilization Validation Senior Engineer

2 H-1B filings at SHIRE HUMAN GENETIC THERAPIES

$140,000
+12% vs company median
3

Senior Validation Engineer

4 H-1B filings at SHIRE HUMAN GENETIC THERAPIES

$120,000
-4% vs company median
4

Research Scientist

3 H-1B filings at SHIRE HUMAN GENETIC THERAPIES

$117,000
-6% vs company median
5

Project Manager

2 H-1B filings at SHIRE HUMAN GENETIC THERAPIES

$110,000
-12% vs company median
6

Associate Research Scientist

2 H-1B filings at SHIRE HUMAN GENETIC THERAPIES

$75,000
-40% vs company median

Salary data based on 110 certified H-1B labor condition applications at SHIRE HUMAN GENETIC THERAPIES. Actual compensation may vary based on experience, specific role requirements, and location within the company.

Highest Individual H-1B Salaries at SHIRE HUMAN GENETIC THERAPIES

Actual filed salaries — These are the 10 highest individual H-1B salary filings at SHIRE HUMAN GENETIC THERAPIES, representing specific positions (not aggregated medians). These may include executive, highly specialized, or senior leadership roles.

The highest H-1B salary filed at SHIRE HUMAN GENETIC THERAPIES was $225,000 for a Director, Head Of Manufacturing Science Downstream position in Lexington, MA (FY2025). This is 80% higher than the company's median H-1B salary.

Top H-1B salaries often cluster in high cost-of-living metros like San Francisco, New York, and Seattle where prevailing wages are higher. However, executive and specialized roles can command premium compensation regardless of location. These filings represent the upper bound of H-1B compensation at SHIRE HUMAN GENETIC THERAPIES—actual total compensation may be significantly higher when including stock grants, bonuses, and benefits. Geographic patterns in top salaries often reflect where companies locate their most senior technical talent and leadership positions.

Rank Job Title Location Salary Level Year
1 Director, Head Of Manufacturing Science Downstream Lexington, MA $225,000 IV FY 2025
2 Team Lead, Device Regulatory Affairs, Pdt Bu Lexington, MA $210,251 IV FY 2024
3 Head/Director, Human Factors And User Research Lexington, MA $206,193 IV FY 2021
4 Team Lead, Global Reg Affairs Device, Pdt Lexington, MA $204,127 IV FY 2023
5 Director, Quality Risk Management Lexington, MA $197,450 IV FY 2024
6 Associate Director, Operations Technology Lexington, MA $195,000 IV FY 2022
7 Product Quality Lead Lexington, MA $195,000 IV FY 2024
8 Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu Lexington, MA $192,000 IV FY 2020
9 Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu Lexington, MA $192,000 IV FY 2020
10 Human Factors Engineering Lead Lexington, MA $190,000 IV FY 2020

These represent the highest individual salary amounts filed in H-1B labor condition applications. Note: H-1B salary data reflects base compensation only and does not include stock options, RSUs, bonuses, or other benefits which can significantly increase total compensation at tech companies.

Detailed Breakdown

H-1B Job Titles at SHIRE HUMAN GENETIC THERAPIES

Job Title Filings Median Salary
Senior Validation Engineer 4 $120,000
Research Scientist 3 $117,000
Project Manager 2 $110,000
Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu 2 $192,000
Associate Research Scientist 2 $75,000
Cleaning And Sterilization Validation Senior Engineer 2 $140,000

H-1B Locations for SHIRE HUMAN GENETIC THERAPIES

Location Filings Median Salary
Lexington, MA 80 $120,422
Cambridge, MA 25 $137,000
Exton, PA 2 $62,000
Leexington, MA 1 $176,105
Natick, MA 1 $85,000
Fitchburg, MA 1 $130,000

Recent H-1B Filings at SHIRE HUMAN GENETIC THERAPIES

Sample of 20 recent certified H-1B labor condition applications. This represents a small fraction of SHIRE HUMAN GENETIC THERAPIES's 110 total certified filings.

Job Title Location Salary Level Year
Validation Manager Lexington, MA $169,914 IV FY 2026
Senior Manager, Process Engineering Lexington, MA $160,775 I FY 2025
Director, Head Of Manufacturing Science Downstream Lexington, MA $225,000 IV FY 2025
Quality Manager - QA Operations Lexington, MA $147,733 IV FY 2025
Automation Engineer Lexington, MA $93,000 I FY 2025
Senior Process Validation Engineer I Lexington, MA $109,781 II FY 2025
Digital Analyst Fitchburg, MA $130,000 II FY 2024
Digital Analyst Lexington, MA $130,000 II FY 2024
Quality Disposition Manager Lexington, MA $139,252 III FY 2024
Sr. Validation Engineer Lexington, MA $130,000 IV FY 2024
Validation Engineer II Lexington, MA $98,000 II FY 2024
Team Lead, Device Regulatory Affairs, Pdt Bu Lexington, MA $210,251 IV FY 2024
Regulatory Lead Cambridge, MA $152,193 IV FY 2024
Senior Validation Engineer II Lexington, MA $154,166 III FY 2024
Regulatory Lead Cambridge, MA $152,193 IV FY 2024
Director, Quality Risk Management Lexington, MA $197,450 IV FY 2024
Product Quality Lead Lexington, MA $195,000 IV FY 2024
Senior Engineer II Lexington, MA $138,820 III FY 2024
Cmc Submission Lead Lexington, MA $97,000 III FY 2024
Research Scientist Lexington, MA $106,012 II FY 2024

Data source: U.S. Department of Labor LCA Disclosure Files. Showing most recent certified filings.

Frequently Asked Questions about SHIRE HUMAN GENETIC THERAPIES H-1B Visas

What is the average H-1B salary at SHIRE HUMAN GENETIC THERAPIES?

The median H-1B salary at SHIRE HUMAN GENETIC THERAPIES is $125,000, based on 110 certified filings from FY 2020 to FY 2026. This is 4% higher than the national H-1B median salary of $120,000. Compensation at SHIRE HUMAN GENETIC THERAPIES reflects their market positioning, with entry-level roles starting around $104,000 and senior positions reaching $180,250 or higher. These figures represent base salaries in LCA filings and may not include bonuses, equity grants, or other compensation common at large employers.

10th %ile Median 90th %ile
$85,000 $125,000 $180,250

Salaries at SHIRE HUMAN GENETIC THERAPIES range from $85,000 at the 10th percentile to $180,250 at the 90th percentile, showing a $95,250 spread across experience levels and roles. The 25th percentile is $104,000 and the 75th percentile is $152,193.

Does SHIRE HUMAN GENETIC THERAPIES sponsor H-1B visas?

Yes, SHIRE HUMAN GENETIC THERAPIES actively sponsors H-1B visas and has been a consistent participant in the H-1B program. They have filed 115 H-1B labor condition applications from FY 2020 to FY 2026, demonstrating ongoing commitment to hiring international talent. With 110 certified applications and a 0% denial rate, SHIRE HUMAN GENETIC THERAPIES maintains a strong track record for H-1B sponsorship. The company sponsors positions across multiple job categories and locations, making them a viable option for professionals seeking H-1B visa sponsorship.

H-1B Filing History
20
21
22
23
24
25
26

In the most recent fiscal year (FY 2026), SHIRE HUMAN GENETIC THERAPIES filed 1 H-1B applications, with 1 certified and 0 denied. Over 7 years of data, SHIRE HUMAN GENETIC THERAPIES has consistently demonstrated commitment to H-1B sponsorship.

Note: These are Labor Condition Applications (LCAs) filed with the Department of Labor, which is a prerequisite for H-1B petitions. The actual number of H-1B petitions filed with USCIS may differ.

What is SHIRE HUMAN GENETIC THERAPIES's H-1B approval rate?

SHIRE HUMAN GENETIC THERAPIES's LCA (Labor Condition Application) denial rate is 0%, with 0 out of 115 applications denied across all years. This translates to a 100.0% certification rate, which indicates how successfully the company prepares and files H-1B applications. A lower denial rate suggests better compliance with Department of Labor requirements, proper wage documentation, and accurate job classification. Prospective H-1B applicants should consider this approval rate alongside other factors like salary, job role, and location when evaluating SHIRE HUMAN GENETIC THERAPIES as a potential H-1B sponsor.

Approval vs Denial Rate
100.0% Certified
110 certified 0 denied

This is an excellent approval rate, indicating SHIRE HUMAN GENETIC THERAPIES has strong H-1B sponsorship practices and typically meets DOL requirements. Applicants can feel confident in the company's H-1B track record.

What jobs does SHIRE HUMAN GENETIC THERAPIES sponsor for H-1B?

SHIRE HUMAN GENETIC THERAPIES sponsors H-1B visas for various specialty occupation positions requiring at least a bachelor's degree. Based on 110 certified filings, the most commonly sponsored job titles reflect the company's primary business functions and talent needs. These positions typically require specialized knowledge in fields like technology, engineering, finance, or scientific research. Understanding which roles SHIRE HUMAN GENETIC THERAPIES most frequently sponsors can help job seekers target their applications effectively.

Most common H-1B job titles at SHIRE HUMAN GENETIC THERAPIES:

Senior Validation Engineer
$120,000
Research Scientist
$117,000
Project Manager
$110,000
Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu
$192,000
Associate Research Scientist
$75,000

The most frequently sponsored role is Senior Validation Engineer with 4 filings at a median salary of $120,000. This is followed by Research Scientist (3 filings) and Project Manager.

Where are SHIRE HUMAN GENETIC THERAPIES's H-1B jobs located?

SHIRE HUMAN GENETIC THERAPIES's H-1B positions are distributed across multiple U.S. locations, with concentration in major metropolitan areas and tech hubs. Geographic distribution often reflects company office locations, client sites, and regional market demands. Location significantly impacts H-1B salary due to varying cost of living and local wage requirements. Understanding where SHIRE HUMAN GENETIC THERAPIES sponsors H-1B workers can help candidates target specific offices and negotiate appropriate compensation for each market.

Top SHIRE HUMAN GENETIC THERAPIES H-1B locations:

The largest H-1B hub for SHIRE HUMAN GENETIC THERAPIES is Lexington, MA with 80 filings at a median salary of $120,422. The highest-paying location is Leexington, MA at $176,105 median. Salaries range from $62,000 to $176,105 across office locations.

How have SHIRE HUMAN GENETIC THERAPIES's H-1B salaries changed over time?

SHIRE HUMAN GENETIC THERAPIES's median H-1B salary has increased by +46% from FY 2020 ($116,000) to FY 2026 ($169,914). Tracking salary trends over time reveals how SHIRE HUMAN GENETIC THERAPIES adjusts compensation to remain competitive in the H-1B labor market. Salary growth typically reflects inflation adjustments, increased demand for specialized skills, and evolving prevailing wage requirements. These historical trends can help applicants understand future salary expectations and negotiate appropriately when considering H-1B opportunities at SHIRE HUMAN GENETIC THERAPIES.

Median Salary Trend
20
21
22
23
24
25
26

Year-by-year breakdown:

  • FY 2022: $125,000 (14 certified)
  • FY 2023: $154,295 (6 certified)
  • FY 2024: $130,000 (17 certified)
  • FY 2025: $147,733 (5 certified)
  • FY 2026: $169,914 (1 certified)

This 46% growth reflects strong compensation adjustments at SHIRE HUMAN GENETIC THERAPIES, keeping pace with market demands for H-1B talent.

What wage level does SHIRE HUMAN GENETIC THERAPIES use for H-1B?

SHIRE HUMAN GENETIC THERAPIES primarily files H-1B applications at Wage Level IV, accounting for 42% of their filings. DOL wage levels range from Level I (entry-level, 17th percentile of local wages) to Level IV (expert, 67th percentile). Wage level determines both salary requirements and, under recent H-1B rules, lottery selection priority. Higher wage levels receive preference in the H-1B lottery, making SHIRE HUMAN GENETIC THERAPIES's wage level distribution an important factor for prospective applicants assessing their chances of H-1B selection.

Wage Level Distribution
I
II
III
IV
I: 16% II: 27% III: 16% IV: 42%

With 84% of positions at Level II or higher, SHIRE HUMAN GENETIC THERAPIES typically offers competitive wages above entry-level. Higher wage levels receive priority in the H-1B lottery.

How does SHIRE HUMAN GENETIC THERAPIES's H-1B salary compare to other employers?

SHIRE HUMAN GENETIC THERAPIES's median H-1B salary of $125,000 is 4% higher than the national H-1B median of $120,000 across all employers and industries. This comparison provides context for evaluating SHIRE HUMAN GENETIC THERAPIES's competitiveness in attracting H-1B talent. Keep in mind that industry, location, and job function significantly impact salary levels. Tech companies and financial institutions typically offer higher H-1B salaries than other sectors, while salaries in major metros like San Francisco and New York exceed those in smaller markets. Compare SHIRE HUMAN GENETIC THERAPIES's offerings with similar companies in your field for a more accurate assessment.

vs National H-1B Median
SHIRE HUMAN GENETIC THERAPIES
$125,000
National
$120,000
+4% above national median

SHIRE HUMAN GENETIC THERAPIES offers above-average H-1B compensation. Combined with their 110 certified filings and 0% denial rate, they demonstrate solid H-1B sponsorship practices.

How do new H-1B fees and rules affect SHIRE HUMAN GENETIC THERAPIES's sponsorship?
Estimated H-1B Sponsorship Costs (FY 2025)
I-129 Base Filing Fee $1,655
ACWIA Fee (25+ employees) $1,500
Fraud Prevention Fee $500
Asylum Program Fee $600
H-1B Registration Fee $215
Estimated Total per H-1B $4,470 - $7,275+

Recent H-1B rule changes have increased filing fees and introduced wage-level prioritization in the lottery. SHIRE HUMAN GENETIC THERAPIES's higher proportion of Level III-IV positions (57%) may benefit from wage-based lottery prioritization.

With 110 certified filings, SHIRE HUMAN GENETIC THERAPIES invests significantly in H-1B sponsorship. The company's 0% denial rate suggests strong compliance with H-1B requirements and documentation standards.

Note: H-1B regulations are subject to change. Fees shown are estimates based on 2024 USCIS fee schedules. Actual costs may vary based on company size, premium processing, and future rule changes.

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